The International Workshop on Acoustic Signal Enhancement (IWAENC 2012) is the thirteenth event in a series of workshops and will be held in the SuperC building at RWTH Aachen University, September 4-6, 2012, Aachen, Germany. The workshop will focus on theory and algorithms for digital enhancement of acoustic signals as well as on signal processing applications in e.g. digital cell phones, audio-visual conferencing systems, voice control systems, and hearing aids. The three day program consists of oral and poster presentations, keynote talks, and demonstrations.